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Mabel Magazine

Psilocybin microdosing & autoimmune diseases

Living with an autoimmune condition

It can feel like a constant battle, managing chronic fatigue, pain, brain fog, and the unpredictability of flare-ups. Even if you do everything right, it still feels like your body is working against you. Though it's not a comfort, know that you are not alone, autoimmune diseases quietly affect millions of women, making up 80% of all cases. 

These conditions are as varied as they are complex, including well-known ones like rheumatoid arthritis, multiple sclerosis, and scleroderma, which often bring their own unique challenges.

This disproportionate rate is not random though, Dr. Howard Chang, MD, PhD, professor of dermatology and genetics at Stanford, explains:


“As a practicing physician, I see a lot of lupus and scleroderma patients, because those autoimmune disorders manifest in skin. The great majority of these patients are women.”

Why are women more likely to have autoimmune diseases?

Women have two X chromosomes, each containing hundreds of essential genes. To prevent overproduction, one X chromosome is usually silenced in a process called X-chromosome inactivation. However, this process isn’t perfect and may contribute to immune system dysfunction, making women more susceptible to autoimmune diseases.

The emotional toll can be just as exhausting as the physical symptoms. Stress, anxiety, and even depression often goes hand in hand with these conditions, leaving you wondering if there’s ever a way to feel like yourself again.

How microdosing psilocybin can help ease symptoms of autoimmune diseases.

At Mabel, we believe microdosing psilocybin might offer some relief. Known for its benefits in supporting mental health, this natural compound also has the potential to reduce inflammation, positively affect the brain, and help manage the overwhelming stress that often fuels autoimmune conditions.

As Autoimmune diseases are complex, influenced by factors like inflammation, chronic stress, and imbalances in the immune system there are several compelling reasons for why microdosing psilocybin might help you feel like yourself again, or at least ease up some of the symptoms. 

Ease the mental load

Living with an autoimmune condition is emotionally draining. Psilocybin’s ability to reduce stress and calm the nervous system can go a long way in easing that constant pressure, allowing you some space to breathe again.

Reduce inflammation

Chronic inflammation is akin to a fire that won't go out. Psilocybin has shown promise in reducing key inflammatory markers, potentially aiding your system from the inside out.

Encourage neural repair

Brain fog, forgetfulness, and mental fatigue often adds to the burden and affects work quality creating even more stress. Psilocybin allows for neuroplasticity, helping your brain adapt and heal.

Release emotional weight

The stress and trauma of managing a chronic condition can weigh heavily on anyone. Psilocybin-assisted therapy offers a way to gently explore and release that burden, helping you find clarity and emotional balance.

Supporting your gut-brain connection

If digestive issues are part of your experience, you’re not imagining the connection. Stress and inflammation often disrupt gut health. Psilocybin’s impact on the gut-brain axis may help restore that balance and ease the discomfort.

Not a quick fix

Living with an autoimmune condition can be both isolating and overwhelming and though microdosing with psilocybin isn’t a quick fix, it can offer subtle, supportive ways to explore relief, physically, mentally, and emotionally.

At Mabel, we’re here to help you take the first step toward balance and resilience. Let’s explore this journey together. Our Mindful Microdosing Program is a 5 week at-home course merging microdosing, neuroscience and psychology. Dr Shauna Shapiro will be your coach and guide through this practice, leaving you with a feeling of newfound appreciation of life and yourself.  

Who knows, maybe the best is yet to come. 

Disclaimer: This content is for informational purposes only and not medical advice.